產品貨號 : mlR20324
英文名稱 : CD43
中文名稱 : CD43抗體
別 名 : CD 43; CD43; CD43 antigen; Galactoglycoprotein; Galactoglycoprotein; GALGP; GPL 115; GPL115; Human gene for sialophorin; Leucocyte sialoglycoprotein; Leucocyte sialoglycoprotein; LEUK_HUMAN; Leukocyte sialoglycoprotein; Leukosialin; LSN; Sialophorin (leukosialin); Sialophorin; SPN.
研究領域 : 免疫學 干細胞 細胞類型標志物 淋巴細胞 t-淋巴細胞 b-淋巴細胞
抗體來源 : Rabbit
克隆類型 : Polyclonal
交叉反應 : Human, Mouse, Rat,
產品應用 : WB=1:500-2000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 38kDa
細胞定位 : 細胞膜
性 狀 : Lyophilized or Liquid
濃 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CD43:101-200/400 <Extracellular>
亞 型 : IgG
純化方法 : affinity purified by Protein A
儲 存 液 : Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
產品介紹background:
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011].
Function:
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.
Subunit:
Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Post-translational modifications:
Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
SWISS:
P16150
Gene ID:
6693
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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