產(chǎn)品貨號 :  mlR10070

英文名稱 :  IL-31

中文名稱 :  白細(xì)胞介素31抗體

別  名 :  Interleukin-31; 1700013B14RIK; IL31; interleukin-31 precursor; IL 31; IL-31; IL31_HUMAN; IL31_MOUSE; Interleukin 31.  

研究領(lǐng)域 :  細(xì)胞生物  免疫學(xué)  

抗體來源 :  Rabbit

克隆類型 :  Polyclonal

交叉反應(yīng)  :  Mouse, Rat,

產(chǎn)品應(yīng)用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  16kDa

細(xì)胞定位 :  分泌型蛋白

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from rat IL-31:21-120/163

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產(chǎn)品介紹 :   IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

Function:

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.

Subcellular Location:

Secreted.

Tissue Specificity:

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.

SWISS:

Q6EBC2

Gene ID:

76399

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IL-31是一種新型T細(xì)胞衍生的細(xì)胞因子,其功能受體復(fù)合物是由IL-31RA/GPL/GLM R和OSMR組成的異二聚體。它們在過敏性和非過敏性疾病中起重要作用。

產(chǎn)品圖片