產品貨號 : mlR17695
英文名稱 : phospho-MNK1 (Thr385)
中文名稱 : 磷酸化MAP激酶相互作用絲氨酸/蘇氨酸激酶1抗體
別 名 : MNK1 (phospho T385); p-MNK1 (phospho T385); MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal integrating kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal integrating kinase 1; MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1; MKNK1; MKNK1_HUMAN; MNK 1; Mnk1.
產品類型 : 磷酸化抗體
研究領域 : 細胞生物 信號轉導 激酶和磷酸酶
抗體來源 : Rabbit
克隆類型 : Polyclonal
交叉反應 : Human,
產品應用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 51kDa
細胞定位 : 細胞核 細胞漿
性 狀 : Lyophilized or Liquid
濃 度 : 1mg/ml
免 疫 原 : KLH conjugated synthesised phosphopeptide derived from human MNK1 around the phosphorylation site of Thr385:LP(p-T)P
亞 型 : IgG
純化方法 : affinity purified by Protein A
儲 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
產品介紹 : This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Function:
May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Subcellular Location:
Cytoplasm and Cytoplasm. Nucleus.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.
Similarity:
Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
SWISS:
Q9BUB5
Gene ID:
8569
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品圖片
