產(chǎn)品貨號 :  mlR18045

英文名稱 :  HLF

中文名稱 :  白血病抑制因子抗體

別    名 :  Hepatic leukemia factor; Hlf; HLF/E2A FUSION GENE; HLF_HUMAN.  

研究領(lǐng)域 :  腫瘤  細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  

抗體來源 :  Rabbit

克隆類型 :  Polyclonal

交叉反應(yīng) :  Human, Mouse, Rat, Cow, Horse,

產(chǎn)品應(yīng)用 :  ELISA=1:500-1000  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  33kDa

細(xì)胞定位 :  細(xì)胞核

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human HLF:201-295/295

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產(chǎn)品介紹 :  This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Function:

Highly expressed in liver; lower levels in lung and kidney.

Subcellular Location:

Nucleus.

DISEASE:

Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Similarity:

Belongs to the bZIP family. PAR subfamily.

Contains 1 bZIP domain.

SWISS:

Q16534

Gene ID:

3131

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.