產品貨號 :  mlR18173

英文名稱 :  Intrinsic Factor

中文名稱 :  胃內在因子抗體

別    名 :  Gastric Intrinsic Factor; Gastric intrinsic factor (vitamin B synthesis); GIF; IF; IFMH; INF; Intrinsic factor; TCM3; TCN3.  

研究領域 :  細胞生物  免疫學  信號轉導  

抗體來源 :  Rabbit

克隆類型 :  Polyclonal

交叉反應 :  Human, Mouse, Rat,

產品應用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  43kDa

細胞定位 :  分泌型蛋白

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Intrinsic Factor:321-417/417

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產品介紹 :  This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

Function:

Intrinsic factor promotes absorption of the essential vitamin Cobalamin (Cbl) in the ileum by specific receptor mediated endocytosis. Defects in the gene GIF are the cause of hereditary intrinsic factor deficiency (IFD) also called congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia. 

Subcellular Location:

Secreted 

Tissue Specificity:

Gastric mucosa.

DISEASE:

Hereditary intrinsic factor deficiency (IFD)

Similarity:

Belongs to the eukaryotic cobalamin transport proteinsfamily.

SWISS:

P27352 

Gene ID:

2694

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.