產品貨號 :  mlR7492

英文名稱 :  PLXNC1/CD232

中文名稱 :  細胞表面蛋白CD232抗體

別    名 :  CD232; Plexin-C1; PLXC1_HUMAN; Plxnc1; Virus-encoded semaphorin protein receptor.   

研究領域 :  細胞生物  神經生物學  細胞膜受體  

抗體來源 :  Rabbit

克隆類型 :  Polyclonal

交叉反應 :  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,

產品應用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  172kDa

細胞定位 :  細胞膜

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PLXNC1/CD232:681-780/1568 <Extracellular>

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產品介紹 :  This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

Function:

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.

Subcellular Location:

Membrane.

Tissue Specificity:

Detected in heart, brain, lung, spleen and placenta.

Post-translational modifications:

N-glycosylated.

Similarity:

Belongs to the plexin family.

Contains 1 Sema domain.

SWISS:

O60486

Gene ID:

10154 

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.