產品貨號 :  mlR20054

英文名稱 :  phospho-DAP Kinase 1 (Ser308)

中文名稱 :  磷酸化凋亡相關蛋白激酶1抗體

別    名 :  DAP Kinase 1 (phospho Ser308); DAP Kinase 1 (phospho S308); DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death Associated Protein Kinase 1; Death-associated protein kinase 1; DKFZp781I035;  

研究領域 :  腫瘤  細胞生物  信號轉導  細胞凋亡  新陳代謝  

抗體來源 :  Rabbit

克隆類型 :  Polyclonal

交叉反應 :  Human, Mouse, Rat,

產品應用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  157kDa

細胞定位 :  細胞漿

性    狀 :  Lyophilized or Liquid

濃    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthesised phosphopeptide derived from human DAP Kinase 1 around the phosphorylation site of Ser308:KQ(p-S)VR

亞    型 :  IgG

純化方法 :  affinity purified by Protein A

儲 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

產品介紹 :  DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Function:

Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.

Subcellular Location:

Cytoplasm. Colocalizes with the actin filament system.

Post-translational modifications:

Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.

Similarity:

Belongs to the protein kinase superfamily.

CAMK Ser/Thr protein kinase family.

DAP kinase subfamily.

SWISS:

P53355

Gene ID:

1612

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.